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@article{161156, author = {Gangu Sreelatha and N. Sai Lokesh and Kaluvala Ramya}, title = {A Simple UV Spectrophotometric Method Development and Validation of Melatonin in its Bulk and Pharmaceutical Dosage Forms}, journal = {International Journal of Innovative Research in Technology}, year = {}, volume = {10}, number = {2}, pages = {775-778}, issn = {2349-6002}, url = {https://ijirt.org/article?manuscript=161156}, abstract = {A simple and sensitive UV Spectrophotometric method has been developed for the quantitative estimation of Melatonin in its bulk and pharmaceutical dosage form. The drug showed maximum absorbance at 225nm. Regression analysis of Beer’s plot showed correlation of 0.998 in the concentration range of 1.5-7.5 μg/ml and the percentage recovery was between 98-102% indicting high degree of accuracy. The % RSD of intra-day and inter-day precision was found to be less than 2 as per ICH guidelines. Sensitivity of the method was confirmed by accurate LOD and LOQ values which were obtained 0.23 and 0.698 respectively.}, keywords = {Melatonin, Spectroscopic method development, validation, ICH Guidelines.}, month = {}, }
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