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@article{161180,
        author = {Gangu Sreelatha and Thummanapalli Priyanka and K. Ratna Jyothi},
        title = {A new method Development and Validation of Agomelatine by RP-HPLC in its bulk and tablet dosage form},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {10},
        number = {2},
        pages = {857-863},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=161180},
        abstract = {A novel and simple Reverse phase liquid chromatographic method was established for the determination of Agomelatine in presence of degradants. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. It is used for the treatment of major depressive disorder. The proposed work was performed on Thermo Hypersil extended C18 column (250 mm × 4.6 mm i.e., 5 µm particle size) using a mixture of Buffer (4.3pH) and methanol (60:40) as mobile phase with flow rate 1.0 ml/min. Water and Methanol (50:50) was used as diluent. The retention time was found to be 3.374 min. The linearity range used was 25-75µg/ml. The %RSD was found to be less than 2%. LOD & LOQ values were found to be 3.3002 and 10.0008µg/ml respectively.},
        keywords = {Agomelatine, Antagonist, Chromatography, Buffer, Depressive Disorder.},
        month = {},
        }