Formulation and Evaluation of Sustained Release Matrix Tablets of Ramipril by using Natural and Synthetic Polymers

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Angilicam Avinash; Chata Aparna; Mallemkondu Balaji; Pothireddy Suresh Sukhetha; Sangeetham Sujithnarayana; Thalari Sneha

Formulation and Evaluation of Sustained Release Matrix Tablets of Ramipril by using Natural and Synthetic Polymers

Authors: Angilicam Avinash , Chata Aparna, Mallemkondu Balaji, Pothireddy Suresh Sukhetha, Sangeetham Sujithnarayana, Thalari Sneha

Unique Paper ID: 161253
Volume: 10
Issue: 3
PageNo: 96-103

Keywords: Bioavailability Okra gum Pectin Ramipril Sustained release.

Abstract:
Sustained release systems include any drug delivery system that achieves slow release of drug over an extended period of time. If the system is successful in maintaining constant drug levels in the blood or target tissue, it is considered as a controlled-release system. Ramipril is an antihypertensive agent used in the treatment and management of hypertension. Ramipril has low bioavailability (28%) and short biological half-life (2-4 hrs) favours for the development of sustained release tablets. The aim of the research work is to formulate and evaluate ramipril sustained release tablets in order to enhance bioavailability by maintaining prolonged therapeutic concentrations in plasma. Natural polymers like pectin and okra gum were extracted from orange peel and ladies finger respectively. Nine formulations of ramipril containing varying concentrations of polymers (pectin, okra gum and HPMC K15M) were designed. The sustained release tablets of ramipril were prepared by wet granulation method. FT-IR studies revealed that no interaction between drug and polymers. The powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausnerâ€™s ratio; all these values are within the specified limit which indicates good flow properties. The prepared tablets were evaluated for physicochemical parameters such as thickness, weight variation, hardness, friability and drug content. In vitro release studies revealed that out of 9 formulations, formulation F9 was found to be optimized which showed sustained drug release of 99.42% for 12 hours.

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ISSN: 2349-6002
Volume: 10
Issue: 3
PageNo: 96-103

Formulation and Evaluation of Sustained Release Matrix Tablets of Ramipril by using Natural and Synthetic Polymers

Available:https://ijirt.org/article?manuscript=161253

01 Sep, 2023

Design and In-vitro Characterization of Domperidone Oral Thin Films

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UGC Approved
Journal no 47859

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