STUDY OF PHARMACOKINETIC ASSESSMENT OF BILASTINE-LOADED GASTRORETENTIVE FLOATING TABLETS

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Ranjith Kumar Ambati; Dr Pabba Parameshwar

STUDY OF PHARMACOKINETIC ASSESSMENT OF BILASTINE-LOADED GASTRORETENTIVE FLOATING TABLETS

Authors: Ranjith Kumar Ambati, Dr Pabba Parameshwar

Unique Paper ID: 162475
Volume: 10
Issue: 10
PageNo: 964-976

Keywords: bilastine gastroretentive pharmacokinetic profile.

Abstract:
This study investigates the pharmacokinetic profile of bilastine-loaded gastroretentive floating tablets. Bilastine, an antihistamine, is utilized for its potential in managing allergic conditions. The formulation involves the development of gastroretentive tablets to enhance drug bioavailability and optimize therapeutic efficacy. The research encompasses the formulation of bilastine-loaded gastroretentive floating tablets and subsequent in vitro characterization. The pharmacokinetic evaluation is conducted through a well-designed study involving an appropriate animal model. Parameters such as maximum plasma concentration (Cmax), time to reach Cmax (Tmax), and area under the concentration-time curve (AUC) are analysed to assess the drug's absorption, distribution, and elimination. The results reveal crucial insights into the pharmacokinetic behaviour of bilastine when delivered through gastroretentive floating tablets. The discussion interprets these findings, drawing comparisons with existing literature and formulations. The study's implications for advancing drug delivery strategies and optimizing bilastine's therapeutic outcomes are explored.

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Cite This Article

ISSN: 2349-6002
Volume: 10
Issue: 10
PageNo: 964-976

STUDY OF PHARMACOKINETIC ASSESSMENT OF BILASTINE-LOADED GASTRORETENTIVE FLOATING TABLETS

Available:https://ijirt.org/article?manuscript=162475

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