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@article{170401, author = {SAMIKSHA G. DHANUSKAR and KARISHMA A. NIKOSE}, title = {A REVIEW ON STEM CELLS THERAPY: A NEW HOPE FOR NEONATAL AND ADULT BRAIN DAMAGE}, journal = {International Journal of Innovative Research in Technology}, year = {2024}, volume = {11}, number = {7}, pages = {718-723}, issn = {2349-6002}, url = {https://ijirt.org/article?manuscript=170401}, abstract = {After neuronal cell injury, self-neuronal regeneration is frequently minimal or non-existent, necessitating the development of novel methods to cure neurological impairment. Review of the research on stem cell treatment for neurological conditions. Because of their ability to regenerate, stem cells have demonstrated promise in the treatment of a number of neurological conditions and impairments. Early clinical trials and animal models have shown encouraging outcomes from the transplantation or administration of many stem cell types. But there are still issues with their application. It is necessary to decide on the kind of stem cell to be utilized, the best way and route of administration, the quantity of stem cells given, preconditioning, and the injection schedule. For every neurological illness, the review summarizes the main conclusions from current, excellent research, going into cell production, distribution strategies and treatment results. Although the review highlights the capacity of stem cells to directly rebuild brain circuits and replace missing neurons, it also highlights the crucial role that paracrine and immunomodulatory systems play in mediating the therapeutic benefits of stem cells in the majority of neurological illnesses. The essay also examines the difficulties and restrictions involved in implementing stem cell therapy in clinical settings, such as problems with cell source, scalability, safety and regulatory constraints.}, keywords = {Stem Cell Tracking, Neonatal Brain Injury, Neurological Disorders, Routes of Administration, clinical Trials.}, month = {December}, }
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