Formulation And Evaluation Pantoprazole Oral Disintegration Tablet For Pediatric Use

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Miss. Nandinee P. Lavhe; Miss. Varsha A. Bhosale; Miss. Shweta S. Londhe; Miss. Sakshi T. Dombale; Miss. Sneha K. panigrahi

Formulation And Evaluation Pantoprazole Oral Disintegration Tablet For Pediatric Use

Authors: Miss. Nandinee P. Lavhe, Miss. Varsha A. Bhosale, Miss. Shweta S. Londhe, Miss. Sakshi T. Dombale, Miss. Sneha K. panigrahi

Unique Paper ID: 181107
Volume: 12
Issue: 1
PageNo: 3600-3608

Keywords: Pantoprazole Oral Disintegrating Tablets GERD Pediatric Formulation Proton Pump Inhibitors Taste Masking.

Abstract:
Pantoprazole is a widely used proton pump inhibitor (PPI) for managing Gastroesophageal Reflux Disease (GERD), which is a common condition in pediatric patients. The creation of Oral Disintegrating Tablets (ODT) for use in children provides a convenient and patient-friendly form of medication that addresses the issues associated with traditional tablets, including swallowing difficulties and low adherence. In this evaluation, we will examine the formulation approaches, assessment criteria, and real-world effectiveness of Pantoprazole ODT in pediatric patients. Detailed discussion is provided on the challenges related to taste masking, rapid disintegration, and stability of Pantoprazole, an acid-labile drug. The use of super disintegrates and sweeteners in excipient selection are highlight as an advancement to ensure patient acceptability while maintaining therapeutic efficacy. Regulatory considerations specific to pediatric formulations and the impact of ODT on treatment outcomes are also explored in the review. Pantoprazole ODT are seen as a promising alternative for effective GERD management in children as the demand for pediatric-friendly formulations increases, offering enhanced patient compliance and ease of administration. Future prospects include optimizing the formulation for even faster onset of action, improving taste masking techniques, and the potential for personalized ODT using emerging technologies.

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Cite This Article

ISSN: 2349-6002
Volume: 12
Issue: 1
PageNo: 3600-3608

Formulation And Evaluation Pantoprazole Oral Disintegration Tablet For Pediatric Use

Available:https://ijirt.org/article?manuscript=181107

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