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@article{206036,
        author = {Mr. Pratik Laxman Kolte and Dr. Karna B. More},
        title = {Phytochemical Investigation and Pharmacological Evaluation of Butea monosperma root Extract for Antianxiety Activity in Rats},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {40-55},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206036},
        abstract = {The present study was undertaken to investigate the phytochemical constituents and pharmacological potential of Butea monosperma root extract with special emphasis on its antioxidant and antianxiety activities in experimental animals. The plant material was collected, authenticated, dried, and subjected to pharmacogenetic and physicochemical evaluation to confirm its identity and quality. The powdered root material was extracted using different solvents, and the obtained extracts were evaluated for their phytochemical profile and biological activities.
Preliminary phytochemical investigation revealed the presence of various bioactive constituents including alkaloids, flavonoids, glycosides, tannins, phenolic compounds, proteins, and carbohydrates. Quantitative estimation showed the presence of significant amounts of phenolic and flavonoid compounds, indicating the potential antioxidant capacity of Butea monosperma root extracts.
The antioxidant activity was evaluated using the DPPH free radical scavenging method. The extracts demonstrated significant concentration-dependent free radical scavenging activity, suggesting their ability to reduce oxidative stress. The ethanolic extract showed superior antioxidant potential due to the higher content of phenolic and flavonoid constituents.
The pharmacological evaluation of antianxiety activity was carried out using the Elevated Plus Maze (EPM) model in Wistar rats. Treatment with ethanolic and methanolic extracts of Butea monosperma root showed a significant increase in open arm entries and time spent in open arms, along with a reduction in closed arm preference, indicating anxiolytic activity. The observed effect was comparable with the standard anxiolytic drug diazepam.
Acute toxicity studies revealed that the extracts were safe and well tolerated at the tested dose levels. The antianxiety activity of Butea monosperma root extract may be attributed to the presence of phenolic compounds, flavonoids, and other secondary metabolites responsible for neuroprotective and antioxidant effects.
The findings of the present study provide scientific evidence supporting the traditional use of Butea monosperma and suggest its potential as a natural therapeutic agent for the management of anxiety disorders. Further investigations are required for isolation of active phytoconstituents and molecular studies to establish its mechanism of action.},
        keywords = {Butea monosperma root extract, phytochemical investigation, antianxiety activity, antioxidant activity, Elevated Plus Maze, Wistar rats, diazepam.},
        month = {July},
        }