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@article{204290,
        author = {Dr.Pravin Uttekar and Mr.Shubham Balasaheb Jagtap},
        title = {Design and Evaluation of Cefdinir Monohydrate Solid Lipid Nanoparticles Using Various Pharmaceutical Techniques},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {4128-4133},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204290},
        abstract = {Cefdinir monohydrate is a third-generation cephalosporin antibiotic widely used in the treatment of respiratory tract infections, sinusitis, otitis media, skin infections, and other bacterial diseases. However, its poor aqueous solubility and limited oral bioavailability significantly reduce its therapeutic performance. The present research work focuses on the preparation and evaluation of Cefdinir monohydrate-loaded Solid Lipid Nanoparticles (SLNs) using the probe sonication method to improve solubility, stability, dissolution rate, and bioavailability.
Solid Lipid Nanoparticles were prepared using stearic acid as lipid, Span 60 and Tween 80 as surfactants, ethanol as solvent, and mannitol as cryoprotectant. The probe sonication method was selected due to its simplicity, cost-effectiveness, reproducibility, and ability to produce nanosized particles with narrow size distribution. Three formulations (T1, T2, and T3) were developed using varying concentrations of lipid and surfactants.
The prepared SLNs were characterized for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, morphology, pH, viscosity, and in-vitro drug release profile. The optimized formulation showed uniform particle size distribution, satisfactory entrapment efficiency, controlled drug release, and improved physical stability. FTIR studies confirmed compatibility between Cefdinir and selected excipients without any significant chemical interaction.
The results demonstrated that SLNs successfully enhanced the solubility and dissolution profile of Cefdinir monohydrate. The study concluded that SLNs prepared by probe sonication provide a promising approach for improving the therapeutic effectiveness of poorly soluble drugs.},
        keywords = {Cefdinir Monohydrate, Solid Lipid Nanoparticles, Probe Sonication, Nanotechnology, Drug Delivery System, Stability Study, Controlled Release.},
        month = {June},
        }