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@article{206539,
        author = {Mr.Shreyash Bandagr and Dr.Vishal B Babar and Dr.Sudharshan Nagrale},
        title = {A-Review - Synthesis, Characterization, Molecular Docking, and In-Silico ADMET Studies of Quinoline Derivatives},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {2126-2130},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206539},
        abstract = {Quinoline is an important nitrogen-containing heterocyclic scaffold that has attracted considerable attention in medicinal chemistry because of its diverse pharmacological properties. Quinoline derivatives exhibit a broad spectrum of biological activities, including antimicrobial, antimalarial, anticancer, antiviral, anti-inflammatory, antitubercular, and antioxidant effects. Advances in synthetic methodologies have enabled the development of structurally diverse quinoline analogs with enhanced biological activity and improved pharmacokinetic profiles. Modern drug discovery increasingly integrates molecular docking and in-silico ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) studies to predict the binding affinity, pharmacokinetic behavior, and safety of novel compounds before biological evaluation. This review summarizes recent advances in the synthesis, characterization, molecular docking, and in-silico ADMET evaluation of quinoline derivatives. It also discusses structure–activity relationships (SAR), computational approaches, and future perspectives for the rational design of quinoline-based therapeutic agents.},
        keywords = {Quinoline derivatives, Medicinal chemistry, Molecular docking, ADMET, Drug design, Structure–activity relationship, Heterocyclic compounds.},
        month = {July},
        }