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@article{184216,
        author = {Ms. Dewanjali Rathore and Tushar Sharma and Vinay Panagar and Jyoti Patel and Pallavi Deshmukh and Payal gajbhiye and kriti Gandhi},
        title = {"Transdermal Methotrexate Delivery: A Novel Approach for Rheumatoid Arthritis Treatment"},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {4},
        pages = {938-945},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=184216},
        abstract = {The crippling condition known as rheumatoid arthritis (RA) is linked to a higher risk of osteoporosis and cardiovascular disease. There have been reports of poor nutritional status in RA patients, and some medication regimens, including nonsteroidal anti-inflammatory medications (NSAIDs), that are used to treat RA symptoms may make certain nutrients more necessary and decrease their absorption. This study examines the scientific data supporting the use of nutrition supplements and food in the treatment of RA, whether via symptom relief, slowing the disease's development, or minimizing the need for or adverse effects of NSAIDs. Long-chain n-3 polyunsaturated fatty acid (PUFA) supplementation regularly shows a decrease in NSAID use and an improvement in symptoms. Evidence on antioxidants, zinc, iron, folate, other B vitamins, and other fatty acids.
Patients with rheumatoid arthritis (RA), a chronic inflammatory systemic autoimmune disease, experience differing degrees of joint damage. Age, gender, genetics, and environmental exposure (cigarette smoking, air pollution, and occupational exposure) are risk factors. If left untreated, a number of problems may arise, including rheumatoid vasculitis, elty's syndrome, which necessitates a splenectomy, and irreversible joint degeneration that requires arthroplasty. Since there is no known cure for RA, the objectives of therapy are to lessen discomfort and prevent or delay more damage. Here, we provide a concise overview of the many historical and contemporary approaches to treating rheumatoid arthritis-related problems.},
        keywords = {Arthroplasty, NSAIDs, Osteoporosis, Rheumatoid arthritis, Splenectomy},
        month = {September},
        }