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@article{185563,
        author = {Shradha Markam and Yogesh Sharma and Sameer Khan and Sanjay Jatav and Tarun Sahu and Asif Equbal and Dr. Jagdish C. Rathi},
        title = {Formulation of Herbal-Based Biodegradable Patch for Minor Cuts and Burn},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {2177-2181},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185563},
        abstract = {Wound healing is a complicated biological process that involves cellular and molecular events leading to recovery of damaged tissue. Typical wound dressings fail to maintain the best moisture balance, biocompatibility and antimicrobial feature. The present study deals with the development and characterization of herbal-based biodegradable wound-healing patch composed of sodium alginate and pectin integrated with Aloe vera, Neem (Azadirachta indica) and Curcumin (from Curcuma longa) extracts. The prepared patches were characterized for various physicochemical properties, mechanical properties, drug content uniformity, In vitro drug release study and antimicrobial effects, Stability studies. The results indicated smooth, flexible and uniform films with a preferred thickness (0.19–0.25 mm), tensile strength (18.6 ± 1.2 MPa) and elongation (22.5 ± 1.5%). The Drug content uniformity ranged between 94–97%, and sustained release up to 82% was achieved over 24 hours. The films also possessed remarkable antimicrobial activity toward Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, suggesting their broad-spectrum effect. No significant alteration in the physicochemical properties was observed in stability studies. The results suggest that the modified herbal patch provides a potential alternative and biodegradable system for wound healing, which is essentially a combination of therapeutic efficacy of natural extracts and ecologically friendly polymeric substrate.},
        keywords = {Wound healing, Biodegradable film, Aloe vera, Neem, Curcumin.},
        month = {October},
        }