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@article{185846,
        author = {Dr. Samruddhi Vinod Lad},
        title = {ROLE OF GUGGULU IN THE MANAGEMENT OF LIFESTYLE DISORDERS: AN AYURVEDIC AND BIOMEDICAL REVIEW},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {3293-3297},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185846},
        abstract = {Lifestyle disorders such as obesity, dyslipidemia, hypertension, diabetes mellitus, and atherosclerosis have emerged as significant global health challenges, primarily due to sedentary lifestyles, irregular dietary habits, and mental stress. Ayurveda, the ancient science of life, offers a comprehensive and preventive approach for the management of such disorders through its emphasis on diet, lifestyle modification, and herbal formulations. Guggulu (Commiphora mukul), an oleo-gum resin obtained from the plant, is one of the most esteemed Ayurvedic drugs extensively mentioned in classical texts such as Charaka Samhita, Sushruta Samhita, and Bhaishajya Ratnavali. It is renowned for its Lekhana (scraping), Medohara (anti-obesity), Shothahara (anti-inflammatory), and Rasayana (rejuvenative) properties. Traditionally, Guggulu has been indicated in Medoroga, Vata-Kapha disorders, and for Srotoshodhana (cleansing of body channels). From a biomedical perspective, modern research has identified guggulsterones—the principal bioactive compounds of Guggulu—as potent hypolipidemic, antioxidant, anti-inflammatory, and thyroid-stimulating agents. These mechanisms help regulate lipid metabolism, enhance insulin sensitivity, and reduce oxidative stress, thereby preventing cardiovascular and metabolic complications. Guggulu-based formulations such as Triphala Guggulu, Yogaraja Guggulu, Kaishora Guggulu, and Simhanada Guggulu have shown remarkable efficacy in conditions like obesity, arthritis, and metabolic syndrome.Integrating Ayurvedic wisdom with modern biomedical insights highlights Guggulu as a promising bridge between traditional and contemporary medicine in combating lifestyle disorders. However, to ensure its global therapeutic acceptance, further clinical validation, pharmacological standardization, and toxicity profiling are essential. Guggulu thus stands as a natural, evidence-based therapeutic agent offering holistic benefits for modern lifestyle-induced health challenges.},
        keywords = {Guggulu, Commiphora mukul, lifestyle disorders, Ayurveda, obesity, dyslipidemia, metabolic syndrome, antioxidant, hypolipidemic, Rasayana.},
        month = {November},
        }