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@article{187794,
        author = {Ms. Siddhi D. Pawar and Mr. Akshay R. Gadhari},
        title = {FORMULATION AND DEVELOPMENT OF ASPIRIN IMMEDIATE RELEASE TABLET},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {6184-6191},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187794},
        abstract = {Aspirin (acetylsalicylic acid) remains one of the most extensively used analgesic, antipyretic, and antiplatelet agents worldwide, necessitating robust and efficient formulation strategies for its immediate-release (IR) dosage forms. The development of an aspirin IR tablet requires careful consideration of the drug’s physicochemical properties, particularly its susceptibility to hydrolysis and moisture sensitivity, which can influence stability, bioavailability, and therapeutic performance. This review presents a comprehensive overview of the formulation and development approaches employed in designing effective aspirin IR tablets. Key formulation componentsincluding diluents, disintegrants, binders, lubricants, and stabilizersare discussed with emphasis on their functional roles and selection criteria. The importance of disintegration and dissolution performance is highlighted, as these parameters largely determine the rapid onset of action expected from IR formulations. The article also examines processing techniques such as direct compression, dry granulation, and wet granulation, comparing their advantages and limitations in relation to aspirin’s inherent instability. Additionally, quality evaluation parameters including hardness, friability, weight variation, disintegration time, dissolution rate, assay, and stability testing are reviewed to ensure the final product complies with pharmacopeial standards. Recent advancements in excipient technology, particle engineering, and process optimization aimed at enhancing tablet performance and stability are also addressed. By outlining current formulation practices and technological advancements, this review aims to support researchers and formulators in developing safe, effective, and high-quality aspirin immediate-release tablets.},
        keywords = {Aspirin; Acetylsalicylic acid; Immediate-release tablet; Formulation development; Excipients; Disintegration; Dissolution.},
        month = {November},
        }