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@article{187795,
        author = {Ms. Samruddhi S. Pagare and Mr. Akshay R. Gadhari},
        title = {FORMULATION AND EVALUATION OF FLUCONAZOLE 250 mg IMMEDIATE RELEASE TABLET},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {6157-6165},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187795},
        abstract = {Fluconazole, a widely prescribed triazole antifungal agent, is commonly used for the management of systemic and superficial fungal infections. Due to its high oral bioavailability and predictable pharmacokinetic profile, the development of an effective immediate release (IR) tablet formulation is essential to ensure rapid therapeutic action, patient compliance, and consistent drug performance. This review summarizes the formulation strategies, critical material attributes (CMAs), and critical process parameters (CPPs) influencing the development of Fluconazole 250 mg IR tablets. Emphasis is placed on the selection of suitable excipients such as diluents, disintegrants, binders, and lubricants, which play a crucial role in optimizing tablet characteristics including hardness, friability, disintegration time, and dissolution rate. The review further highlights the importance of pre-formulation studies, compatibility assessments through FTIR and DSC, and evaluation parameters as per pharmacopeial standards. In vitro dissolution profiling, kinetic modeling, and stability studies are discussed to establish the quality, safety, and efficacy of the final formulation. Several research studies reporting enhanced dissolution behavior through the incorporation of super disintegrants or solubility enhancers are critically examined. The article concludes that a carefully optimized IR formulation of fluconazole can significantly improve onset of action, ensuring effective antifungal therapy while meeting regulatory requirements for quality and performance. This review provides a consolidated understanding of current advancements, challenges, and formulation considerations pivotal for developing a robust Fluconazole 250 mg immediate release tablet.},
        keywords = {Fluconazole; Immediate Release Tablets; Formulation Development; Dissolution; Pre-formulation Studies; Antifungal Agents; Excipients; Evaluation Parameters.},
        month = {November},
        }