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@article{189234,
        author = {Mr. Sudarshan D.  Ichche and Dr. Shital V. Sirsat},
        title = {FORMULATION AND EVALUATION OF ENTERIC COATED TABLETS OF PANTOPRAZOLE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {4825-4831},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189234},
        abstract = {Pantoprazole is a proton pump inhibitor widely used in the treatment of acid-related gastrointestinal disorders such as gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. Despite its therapeutic effectiveness, pantoprazole is highly unstable in acidic environments and undergoes rapid degradation in gastric fluid, leading to reduced bioavailability and therapeutic failure when administered as conventional oral dosage forms. To overcome this limitation, enteric coating technology has been extensively employed to protect the drug from acidic degradation and ensure its release in the intestinal environment Enteric-coated tablets are designed to resist disintegration in the acidic pH of the stomach while allowing rapid drug release in the higher pH of the intestine. This targeted release not only enhances drug stability but also improves bioavailability and patient compliance. The present review focuses on the formulation and evaluation aspects of enteric coated tablets of pantoprazole, highlighting the rationale behind enteric coating, selection of polymers, formulation techniques, and evaluation parameters. Various formulation strategies, including core tablet development, selection of suitable enteric polymers such as methacrylic acid copolymers and cellulose derivatives, and coating processes, are discussed in detail. Critical evaluation parameters, including pre-compression studies, post-compression characteristics, in-vitro disintegration, dissolution studies in simulated gastric and intestinal fluids, and stability studies are reviewed. The role of enteric coating in enhancing therapeutic efficacy, reducing gastric irritation, and improving drug stability is also emphasised. Overall, enteric-coated tablets of pantoprazole represent an effective and well-established approach for targeted intestinal drug delivery and improved clinical performance.},
        keywords = {Pantoprazole; Enteric coating; Proton pump inhibitors; Delayed-release tablets; Acid-labile drugs; Oral drug delivery; Pharmaceutical formulation; Dissolution studies},
        month = {December},
        }