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@article{189235,
        author = {Mr. Badrinath B. Sanap and Prof. Mr. Sujit Patil},
        title = {A COMPARATIVE STUDY OF APPROACHES TO MODULATE THE PHARMACOTECHNICAL PROPERTIES OF BCS CLASS III DRUG},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {4832-4837},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189235},
        abstract = {Biopharmaceutical Classification System (BCS) Class III drugs are characterized by high aqueous solubility and low intestinal permeability. Although these drugs readily dissolve in gastrointestinal fluids, their oral bioavailability is often limited by poor membrane permeability, rapid gastrointestinal transit, and efflux mechanisms. As a result, modulation of pharmacotechnical properties becomes essential to improve absorption, therapeutic efficacy, and patient compliance. Various formulation and drug delivery strategies have been explored to overcome these challenges and enhance the oral performance of BCS Class III drugs. This review presents a comparative study of different formulation approaches used to modulate the pharmacotechnical properties of BCS Class III drugs. Approaches such as permeability enhancers, solid dispersions, lipid-based drug delivery systems, mucoadhesive systems, polymeric nanoparticles, prodrug strategies, and modified-release formulations are critically evaluated. Each approach is compared based on its mechanism of action, advantages, limitations, and suitability for improving drug permeability and bioavailability. Special emphasis is given to excipient selection, formulation design, and the impact of these strategies on drug stability, dissolution behavior, and intestinal absorption. Furthermore, the review highlights the importance of pharmacotechnical optimization in overcoming formulation challenges associated with BCS Class III drugs. Comparative analysis of conventional and advanced drug delivery systems demonstrates that appropriate modulation strategies can significantly enhance drug absorption without compromising safety.},
        keywords = {BCS Class III drugs; Pharmacotechnical properties; Low permeability drugs; Oral bioavailability; Permeability enhancement; Advanced drug delivery systems; Pharmaceutical formulation; IVIVC},
        month = {December},
        }