Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{191843,
        author = {K.Venkateswarlu},
        title = {Synthesis and Evaluation of Naphthalimides and their Hybrids with Other Heterocyclic Moieties for Anticancer and Antibacterial Activities: A Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {8136-8144},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=191843},
        abstract = {Naphthalimides, particularly 1,8-naphthalimide derivatives, constitute an important class of heterocyclic compounds in medicinal chemistry owing to their distinctive planar aromatic structure, strong DNA-intercalating ability and versatile synthetic accessibility. Over the past two decades, extensive research has demonstrated their potential as anticancer agents, while recent studies have expanded their application towards antibacterial drug discovery. A significant advancement in this field is the molecular hybridisation of naphthalimides with other biologically active heterocyclic moieties, including triazoles, thioureas, hydrazides, coumarins, benzimidazoles and related systems, with the aim of enhancing biological activity, selectivity and multifunctionality. This review critically surveys the reported synthetic strategies for the preparation of naphthalimides and their heterocyclic hybrids, highlighting conventional and green chemistry approaches. It further examines there in vitro and in vivo anticancer and antibacterial activities, with particular emphasis on structure–activity relationship studies and mechanistic insights. Contributions from Indian researchers are discussed in detail, and the relative paucity of comprehensive, region-specific studies from Andhra Pradesh is identified as a key research gap. Overall, the review underscores the therapeutic promise of naphthalimide-based hybrids and outlines future directions for the rational design of novel anticancer and antibacterial agents.},
        keywords = {Naphthalimides, heterocyclic hybrids, anticancer activity, antibacterial activity, synthesis, structure–activity relationship},
        month = {January},
        }