“New Directions in Organocatalysis for Organic Synthesis: A Review”.

  • Unique Paper ID: 192063
  • Volume: 12
  • Issue: 8
  • PageNo: 8541-8551
  • Abstract:
  • Organocatalysis, defined as catalysis mediated by small organic molecules, has emerged as a powerful and sustainable strategy in modern organic synthesis. Over the past two decades, the field has expanded far beyond classical enamine and iminium ion activation to include non-covalent interactions, N-heterocyclic carbene catalysis, and organocatalytic radical processes. Recent years have witnessed particularly significant advances through the integration of organocatalysis with visible-light photoredox catalysis, enabling enantioselective radical transformations that were previously difficult to achieve under metal-free conditions. Parallel progress in chiral Brønsted acid catalysis, bifunctional catalyst design, and cooperative catalytic systems has further broadened the scope and efficiency of asymmetric synthesis. This review critically examines new directions in organocatalysis with emphasis on mechanistic innovations, catalyst development, and environmentally benign methodologies reported in recent literature. Special attention is given to contributions from Indian researchers, including studies originating from Andhra Pradesh, which highlight growing regional engagement with green and scalable organocatalytic processes. By analysing current trends, limitations, and emerging opportunities, this review underscores the continuing importance of organocatalysis as a versatile and sustainable tool for organic synthesis and outlines future perspectives for its wider academic and industrial application.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{192063,
        author = {K.Venkateswarlu},
        title = {“New Directions in Organocatalysis for Organic Synthesis: A Review”.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {8541-8551},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=192063},
        abstract = {Organocatalysis, defined as catalysis mediated by small organic molecules, has emerged as a powerful and sustainable strategy in modern organic synthesis. Over the past two decades, the field has expanded far beyond classical enamine and iminium ion activation to include non-covalent interactions, N-heterocyclic carbene catalysis, and organocatalytic radical processes. Recent years have witnessed particularly significant advances through the integration of organocatalysis with visible-light photoredox catalysis, enabling enantioselective radical transformations that were previously difficult to achieve under metal-free conditions. Parallel progress in chiral Brønsted acid catalysis, bifunctional catalyst design, and cooperative catalytic systems has further broadened the scope and efficiency of asymmetric synthesis. This review critically examines new directions in organocatalysis with emphasis on mechanistic innovations, catalyst development, and environmentally benign methodologies reported in recent literature. Special attention is given to contributions from Indian researchers, including studies originating from Andhra Pradesh, which highlight growing regional engagement with green and scalable organocatalytic processes. By analysing current trends, limitations, and emerging opportunities, this review underscores the continuing importance of organocatalysis as a versatile and sustainable tool for organic synthesis and outlines future perspectives for its wider academic and industrial application.},
        keywords = {organocatalysis, asymmetric synthesis, N-heterocyclic carbenes (NHCs), photoredox–organocatalysis, chiral Brønsted acids, sustainable catalysis, India},
        month = {January},
        }

Cite This Article

  • ISSN: 2349-6002
  • Volume: 12
  • Issue: 8
  • PageNo: 8541-8551

“New Directions in Organocatalysis for Organic Synthesis: A Review”.

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