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@article{193796,
        author = {Pallavi Suresh Kitey and Dr. P.M. Pimpalshende},
        title = {Formulation And Evaluation Of Microspheres By Using Spray Drying Technique},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {1441-1449},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193796},
        abstract = {One NSAID is ketoprofen. medications that don't cause inflammation. medication is a member of the NSAID class. Since it is a BCS class II medication, The work plan has been broken up into various sections. first gathering theoretical data through a review of the literature and a pharmacological profile. The acquisition of materials and their standardization came next. Preformulation experiments were conducted to determine the medication's color, taste, odor, and melting point. The results showed that these characteristics were equal to those specified in the analytical profile of the drug material. There was no interaction between the medicine and carrier, according to the compatibility analysis conducted using FT-IR spectroscopy and an FT-IR spectrophotometer. utilizing ethyl cellulose, Eudragit RS, Eudragit RL, and Eudragit E100 as retreading polymers, the ketoprofen microspheres were created utilizing the spray drying process. A variety of metrics, including practical yield, micromeritic analysis, particle size measurement, drug content, invitro drug release, scanning electron microscopy (SEM), and stability investigations, were assessed for the produced formulations. The Micromeritic investigation revealed that SD had superior flow characteristics. Additionally, it was discovered that the methods used in this study to create spray dried microspheres might result in a formulation with a consistent drug content. Given the medicine Ketoprofen's solubility nature, a dissolution research is crucial. We can learn more about how the medicine will behave within the body by using in vitro sink settings with the appropriate dissolving medium.
The amount of medication solubilized and the rate of dissolution are two factors that are examined in conjunction with the dissolution investigations. An increase in carrier concentration accelerates the rate of dissolution, according to the in-vitro investigation. A higher rate of disintegration was noted in the order of A good solubility profile depends on the medication remaining in its amorphous form in the formulation, which is ensured by stability tests. After two months of stability testing at 40ºC and 75% relative humidity, the chosen optimized formulation was assessed for drug content and dissolution. Physical appearance, drug content, and invitro drug release did not significantly change, according to alter analysis results.},
        keywords = {},
        month = {March},
        }