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@article{196879,
        author = {Dharti Samba Borkar and Dr. P.M. Pimpalshende},
        title = {Formulation And In Vitro Evaluation Of Bilayer Tablet For The Treatment Of Hypertension And Diabetes},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {11},
        pages = {5439-5454},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=196879},
        abstract = {In the present work bi-layer tablet of Aliskiren and Empagliflozin were prepared by wet granulation method. Using super disintegrants such as sodium starch glycolate and croscarmellose for immediate release layer and for sustained release layer polymer like HPMC K4M and HPMC K100M was used. Best formulation of each layer was selected for bi-layer tablet and bilayer tablet were prepared. Bi-layered tablets were subjected to hardness, weight variation, friability, drug content uniformity, in vitro drug release and drug polymer interaction.
The above studies lid to following:
FTIR studies indicate that the drug is compatible with all the excipients.
Both immediate and sustained release layer were prepared by wet granulation method. The prepared tablet of both layers was evaluated for pure and post compression parameters.
The stability research revealed that after three months, the tablets had not changed much.
The produced bilayered tablets using super disintegrants, release retardant polymers, and various excipients were able to display all the characteristics of a Bi-layered tablet, according to the observations.},
        keywords = {},
        month = {April},
        }