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@article{200328,
        author = {BASAVARAJ SHIDAGONNAVAR and PRADEEP B MIRJE and RAVI SONDUR},
        title = {FORMULATION AND IN VITRO EVALUATION OF DONEPEZIL ETHOSOMAL DRUG DELIVERY SYSTEM},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {12},
        pages = {3450-3456},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=200328},
        abstract = {The present study aimed to design, prepare, and evaluate Donepezil-loaded ethosomal vesicles for improved transdermal drug delivery. Eight formulations (F1–F8) were prepared and characterised for particle size, zeta potential, and drug entrapment efficiency (EE). The particle size ranged from 72 to 98 nm, with negative zeta potentials of -20 to -25 mV, indicating stable nanosized vesicles. Drug entrapment efficiency varied between 76.98% and 85.10%, with formulations F6 and F4 showing the highest EE, attributed to optimised lipid-to-drug ratios and favourable vesicle size. SEM analysis confirmed spherical and uniform vesicle morphology. In vitro release studies demonstrated sustained drug release, and kinetic modeling indicated diffusion-controlled release. The optimized formulations remained stable under accelerated conditions for three months. Overall, ethosomal carriers were shown to be an effective and stable system for transdermal delivery of Donepezil, potentially improving bioavailability and patient compliance.},
        keywords = {Donepezil, Ethosomes, FTIR Studies, In vitro drug release studies, Stability studies},
        month = {May},
        }