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@article{204810,
        author = {Mr. Jadhav Siddheshwar Chandrakant and Mr. Pawar Akash Prahlad and Ms. Suryawanshi Anagha . A. and Mr. Gavhane Sandeepan. D. and Mr. Mohammad Zishan Ibrahim},
        title = {DEVELOPMENT AND CHARACTERIZATION OF HERBAL DENTAL GEL CONTAINING MEDICINAL PLANT EXTRACTS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {3743-3756},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204810},
        abstract = {The present study aimed to formulate, optimize, and evaluate an herbal dental gel containing medicinal plant extracts with potential oral healthcare benefits. Herbal extracts of Neem (Azadirachta indica), Clove (Syzygium aromaticum), Tulsi (Ocimum sanctum), and Aloe vera (Aloe barbadensis) were selected based on their reported antimicrobial, anti-inflammatory, antioxidant, analgesic, and wound-healing properties. The plant materials were subjected to hydroalcoholic extraction, and the obtained extracts were evaluated through preliminary phytochemical screening, which confirmed the presence of bioactive constituents such as flavonoids, tannins, phenolics, glycosides, terpenoids, and alkaloids. The herbal dental gel was prepared using Carbopol 934 as a gelling agent along with glycerin, propylene glycol, sodium saccharin, peppermint oil, methyl paraben, and purified water. Six formulations (F1–F6) were developed and optimized using a Box–Behnken Design (BBD) under the Quality by Design (QbD) approach. Neem extract concentration, Carbopol concentration, and glycerin concentration were selected as independent variables, while viscosity, spreadability, and antimicrobial activity were considered as critical response variables.
The prepared formulations were evaluated for appearance, color, odor, homogeneity, pH, viscosity, spreadability, extrudability, gel strength, drug content, antimicrobial activity, and stability. All formulations exhibited acceptable physicochemical characteristics, good homogeneity, suitable pH for oral application, and satisfactory stability. Antimicrobial studies demonstrated significant inhibitory activity against oral pathogenic microorganisms. Among all formulations, F6 showed the highest antimicrobial activity, optimum viscosity, excellent gel strength, satisfactory spreadability, and maximum drug content. Stability studies confirmed that the formulation remained stable throughout the storage period. The results suggest that the optimized herbal dental gel is safe, effective, and suitable for oral healthcare applications. The developed formulation may serve as a promising natural alternative to conventional synthetic dental preparations for the prevention and management of dental plaque, gingivitis, and oral microbial infections.},
        keywords = {Herbal dental gel, Neem, Clove, Tulsi, Aloe vera, antimicrobial activity, Oral healthcare, Box–Behnken Design, Quality by Design, Herbal formulation.},
        month = {June},
        }