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@article{205426,
        author = {Ms. Janakwade Aishwarya Ramesh and Mr. Gavhane Sandeepan. D. and Ms. Suryawanshi Anagha A. and Ms. Kunte Chandrakala Devidas},
        title = {FORMULATION AND EVALUATION OF HERBAL TOOTHPASTE CONTAINING AZADIRACHTA INDICA (NEEM) EXTRACT FOR PREVENTION OF DENTAL CARIES AND MAINTENANCE OF ORAL HYGIENE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {8012-8022},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205426},
        abstract = {The present study aimed to formulate and evaluate a herbal toothpaste containing Azadirachta indica (Neem) extract for the prevention of dental caries and maintenance of oral hygiene. Increasing concern regarding the long-term use of synthetic oral care products and their associated adverse effects has generated significant interest in herbal alternatives possessing antimicrobial and therapeutic properties. Neem has been traditionally used in Ayurveda for oral hygiene due to its well-documented antibacterial, antifungal, anti-inflammatory, and anti-cariogenic activities. Neem leaves were collected, authenticated, shade dried, powdered, and extracted using ethanol by Soxhlet extraction. Nine toothpaste formulations (F1–F9) were prepared using varying concentrations of Neem extract along with calcium carbonate, glycerin, sorbitol, sodium carboxymethyl cellulose, sodium benzoate, peppermint oil, and purified water. The prepared formulations were evaluated for organoleptic characteristics, physicochemical parameters, phytochemical screening, antimicrobial activity, anti-cariogenic activity, and stability studies according to ICH guidelines. The extraction process yielded 17.12% extract, indicating efficient recovery of phytoconstituents. All formulations demonstrated acceptable color, consistency, homogeneity, and pH suitable for oral use. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, polyphenols, and terpenoids. The optimized formulation (F5) exhibited significant antimicrobial activity against Streptococcus mutans, Staphylococcus aureus, and Candida albicans. Anti-cariogenic evaluation showed 74.8% inhibition of biofilm formation, demonstrating effective plaque prevention potential. Stability studies confirmed that the formulation remained stable under both room temperature and accelerated storage conditions without significant changes in physicochemical properties.
The findings suggest that Neem-based herbal toothpaste is a safe, stable, and effective natural formulation with promising potential as an alternative to conventional synthetic toothpaste for maintaining oral hygiene and preventing dental caries.},
        keywords = {Neem, Herbal Toothpaste, Azadirachta indica, Dental Caries, Oral Hygiene, Antimicrobial Activity, Herbal Formulation.},
        month = {June},
        }