Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{204807,
        author = {Mr. Kendre Akshay dnyanoba and Ms. Suryawanshi Anagha . A and Mr. Gavhane Sandeepan. D and Mr. Mohammad Zishan Ibrahim},
        title = {DEVELOPMENT AND CHARACTERIZATION OF MEDICATED JELLY},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {4362-4371},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204807},
        abstract = {The present study was designed to develop and evaluate a medicated jelly formulation using a systematic Design of Experiments (DoE) approach to achieve an optimized drug delivery system with improved physicochemical and therapeutic performance. Medicated jelly is a semi-solid dosage form that offers advantages such as ease of application, non-greasy nature, improved patient compliance, and enhanced drug bioavailability for topical and mucosal delivery. The formulation was prepared using Carbopol 934 as the primary gelling agent along with co-excipients such as glycerin, propylene glycol, and suitable preservatives. Six formulations (F1–F6) were developed using a Box–Behnken Design (BBD) under Response Surface Methodology to evaluate the effect of independent variables including polymer concentration, humectant level, and drug loading on critical quality attributes. The prepared medicated jellies were evaluated for physicochemical parameters such as appearance, pH, viscosity, spread ability, gel strength, drug content, extrudability, in vitro drug release, skin irritation, and stability. All formulations exhibited satisfactory characteristics with pH in the range of 6.2–6.7, good homogeneity, and acceptable stability. The results indicated that formulation variables significantly influenced gel properties and drug release behavior. Among all formulations, F6 was identified as the optimized batch, demonstrating the highest viscosity (5200 cP), excellent drug content (96.3%), and maximum controlled drug release (95.6%). The formulation also showed good stability and no significant skin irritation, confirming its safety and suitability for topical application. The study concludes that the medicated jelly developed using DoE optimization is a promising, stable, and effective drug delivery system with potential for further clinical evaluation and pharmaceutical application.},
        keywords = {Medicated jelly, Carbopol 934, Box–Behnken design, hydrogel, controlled drug delivery, topical formulation},
        month = {June},
        }