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@article{205825,
        author = {Mr. Gotamwad Navnath Govind and Mr. Gavhane Sandeepan. D. and Ms. Suryawanshi Anagha A. and Ms. Kunte Chandrakala Devidas},
        title = {FORMULATION AND EVALUATION OF HERBAL ANTI-ACNE GEL CONTAINING ALOE VERA EXTRACT FOR ANTI-INFLAMMATORY AND ANTI-ACNE ACTIVITY},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {7989-8001},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205825},
        abstract = {Acne vulgaris is one of the most prevalent chronic inflammatory skin disorders affecting adolescents and adults worldwide, characterized by excessive sebum production, follicular blockage, bacterial colonization, and inflammatory lesion formation. Conventional anti-acne therapies such as benzoyl peroxide, retinoids, clindamycin, and systemic antibiotics are widely used; however, prolonged treatment is frequently associated with adverse effects including skin irritation, dryness, photosensitivity, and increasing antibiotic resistance. These limitations have generated significant interest in herbal dermatological formulations as safer and more sustainable alternatives. The present study aimed to formulate and evaluate a herbal anti-acne gel containing Aloe vera Aloe vera extract for anti-inflammatory and anti-acne activity.
Aloe vera extract was prepared by Soxhlet extraction using ethanol and incorporated into Carbopol 934-based gel formulations prepared in nine experimental batches with varying extract and polymer concentrations. The formulations were evaluated for organoleptic properties, physicochemical parameters including pH, viscosity, spreadability, extrudability, homogeneity, and drug content. Biological evaluation included antimicrobial activity against Cutibacterium acnes Cutibacterium acnes, anti-inflammatory activity, skin irritation testing, and stability studies conducted under ICH guidelines. The optimized formulation demonstrated acceptable physicochemical characteristics, significant antibacterial activity, strong anti-inflammatory potential, and excellent formulation stability during storage. The study concluded that Aloe vera-based herbal anti-acne gel possesses promising therapeutic potential as a safe, stable, and effective topical alternative to conventional synthetic anti-acne formulations. Further clinical evaluation is recommended to establish long-term efficacy and therapeutic application in acne management.},
        keywords = {Aloe vera, Herbal Anti-Acne Gel, Acne Vulgaris, Topical Drug Delivery, Cutibacterium acnes Cutibacterium acnes, Anti-Inflammatory Activity.},
        month = {June},
        }