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@article{205681,
        author = {Ms. Ankita Chandrakant Shinde and Kature Vaibhav Rajaram and Vraj R. Patel and Ms. Namita Sunil Sagavekar and Shivam Pal and Sakshi Govinda Badgujar},
        title = {Neurotransmitter Systems and Receptor Dynamics in Depression: Pathophysiology and Therapeutic Perspectives},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {9426-9435},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205681},
        abstract = {Depression isn’t just about feeling down. It’s a tough mental health condition that hangs around, draining your energy and making it hard to think straight. Your quality of life takes a big hit. Underneath it all, the chemicals in your brain start to slip out of balance. Key players like serotonin, norepinephrine, dopamine, and glutamate—important for keeping your mood steady, helping your brain adapt, and even growing new brain cells—just stop working as a team. When their receptors (like 5-HT1A, NMDA, AMPA, and adrenergic receptors) start acting up, everything gets worse. But that’s not the end of the story. The body’s main stress system, the HPA axis, also goes off course. Add on chronic brain inflammation and oxidative stress, and these brain signals get even more tangled.
Research keeps showing that chronic stress, your genes, and slow-building chemical changes all push these problems forward. They reshape key areas in your brain—the prefrontal cortex, hippocampus, and amygdala—leading to lasting changes in how you feel and act. To fight back, doctors use medications like SSRIs, SNRIs, atypical antidepressants, and drugs aimed at NMDA receptors. The idea is to bring those brain chemicals back into balance. But the truth is, these treatments don’t always do the trick. Many people never get the relief they need. That’s why scientists are chasing new options—fast-acting drugs like ketamine, therapies involving psychedelics, and even brain stimulation.
This review gets into how all these things are mixed together—how neurotransmitters and their receptors spiral out of sync, and the new treatments out there aiming to untangle them. If you want anything explained more or have questions, just let me know.},
        keywords = {Depression; Major Depressive Disorder (MDD); Neurotransmitter Systems; Receptor Dynamics; Serotonin; Dopamine; Glutamate; Neuroplasticity; Antidepressants; Therapeutic Targets.},
        month = {June},
        }