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@article{206733,
        author = {Neha Bharti and Neha Gupta and Dr. Isha Rani},
        title = {PHARMACOLOGICAL EVALUATION OF MADHUCA LONGIFOLIA AGAINST ISO-INDUCED MYOCARDIAL INFARCTION IN EXPERIMENTAL RATS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {2767-2777},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206733},
        abstract = {Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide and is primarily associated with oxidative stress, inflammation, and myocardial necrosis. The present study was designed to evaluate the cardioprotective potential of Madhuca longifolia against isoproterenol (ISO)-induced myocardial infarction in experimental rats. Madhuca longifolia, a medicinal plant belonging to the family Sapotaceae, is known for its rich phytochemical composition and diverse pharmacological activities, including antioxidant and anti-inflammatory properties. The cardioprotective activity of Madhuca longifolia was assessed using the isoproterenol-induced myocardial infarction model in Wistar rats. Experimental animals were divided into different groups, including normal control, ISO control, standard treatment, and plant extract-treated groups. Myocardial infarction was induced by subcutaneous administration of isoproterenol. Following treatment, various biochemical parameters such as creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lipid profile, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were evaluated. Histopathological examination of cardiac tissues was also performed to assess myocardial damage and protective effects of the plant extract. Treatment with Madhuca longifolia significantly reduced the elevated levels of cardiac marker enzymes and lipid peroxidation while restoring endogenous antioxidant enzyme levels when compared with the isoproterenol-treated group. Histopathological studies demonstrated marked protection against myocardial necrosis, inflammatory cell infiltration, and structural damage in the treated animals. The observed cardioprotective effect may be attributed to the presence of flavonoids, phenolic compounds, triterpenoids, and other phytoconstituents possessing potent antioxidant and free radical scavenging activities. The findings of the present study suggest that Madhuca longifolia possesses significant cardioprotective activity against isoproterenol-induced myocardial infarction and may serve as a promising natural therapeutic agent for the prevention and management of cardiovascular diseases. Further studies are warranted to isolate the active constituents and elucidate their precise mechanisms of action.},
        keywords = {Madhuca longifolia, Myocardial Infarction, Isoproterenol, Cardioprotective Activity, Oxidative Stress, Antioxidant Activity, Cardiac Biomarkers, Histopathology, Experimental Rats, Medicinal Plants.},
        month = {July},
        }