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@article{206756,
        author = {Mrs. Sheetal Umrajkar and Poonam Namdeo Tidke},
        title = {Design and Synthesis of Novel Pyridine For Antihypertensive Activity},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {2747-2753},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206756},
        abstract = {Hypertension is a major cardiovascular disorder and a leading cause of morbidity and mortality worldwide, necessitating the continuous development of safer and more effective therapeutic agents. Pyridine-containing heterocycles have emerged as important pharmacophores in medicinal chemistry due to their diverse biological activities and favorable pharmacokinetic properties. In the present study, a series of novel substituted 4-amino-2-(substituted phenyl)-6-phenylpyridine-3-carbonitrile derivatives (D1–D5) were designed and synthesized through a one-pot multicomponent reaction involving substituted benzaldehydes, acetophenone, malononitrile, and ammonium acetate under reflux conditions. The synthesized compounds were obtained in good yields ranging from 77.00% to 78.76% and were purified by recrystallization from ethanol. Structural characterization was carried out using thin-layer chromatography (TLC), melting point determination, Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (^1H NMR) spectroscopy, and mass spectrometry. Spectral analyses confirmed the successful formation of the desired pyridine carbonitrile framework and the presence of the respective substituents. The synthesized derivatives exhibited distinct physicochemical properties influenced by the electronic nature of the substituent groups. Halogenated, nitro, methoxy, and hydroxy derivatives demonstrated characteristic spectral and fragmentation patterns consistent with their proposed molecular structures. The presence of pharmacologically relevant pyridine and carbonitrile moieties suggests potential antihypertensive activity and warrants further biological evaluation. The findings indicate that these novel pyridine derivatives may serve as promising lead molecules for the development of new antihypertensive agents with improved therapeutic efficacy and safety profiles.},
        keywords = {Hypertension, Pyridine derivatives, Aminonicotinonitriles, Pyridine-3-carbonitrile, Multicomponent synthesis, FT-IR spectroscopy, ^1H NMR spectroscopy, Mass spectrometry, Heterocyclic compounds, Antihypertensive agents.},
        month = {July},
        }