A NOVEL VALIDATED RP-HPLC METHOD FOR DEVELOPMENT AND ESTIMATION OF ROSIGLITAZONE IN PHARMACEUTICAL DOSAGE FORMS AND RAT PLASMA

Mallikarjun Bere; Dr. Pasham Venkanna

A NOVEL VALIDATED RP-HPLC METHOD FOR DEVELOPMENT AND ESTIMATION OF ROSIGLITAZONE IN PHARMACEUTICAL DOSAGE FORMS AND RAT PLASMA

Authors: Mallikarjun Bere, Dr. Pasham Venkanna

Unique Paper ID: 152469
Volume: 8
Issue: 3
PageNo: 502-509

Keywords: Rosiglitazone (ROZ) Metformin (MF) Rat plasma and RP-HPLC

Abstract:
A Simple and rapid RP-HPLC method has been developed and validation of rosiglitazone (ROZ) bulk and in pharmaceutical dosage forms. Metformin (MF) used as an internal standard (IS), the study was performed on a Develosil ODS HG-5 RP C18 (5ïm,15cmx4.6mm i.d.) with a mobile phase of methanol: potassium dihydrogen phosphate (70:30v/v) as a mobile phase and was delivered at a flow rate of 1.0 ml/min. The detection was carried out at a wavelength of 245nm (Shimadzu-LC 10AD UV detector). The retention time of rosiglitazone was found to be 3.85min respectively. For rosiglitazone, the calibration curve was linear over the concentration range of 120-400 ng/ml for rosiglitazone (UV detector).The method was successfully developed and validated for rosiglitazone estimation, with improved sensitivity, linearity, accuracy and precision as per ICH guidelines and found to be convenient and effective for the estimation of rosiglitazone in pharmaceutical dosage forms and rat plasma.

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ISSN: 2349-6002
Volume: 8
Issue: 3
PageNo: 502-509

A NOVEL VALIDATED RP-HPLC METHOD FOR DEVELOPMENT AND ESTIMATION OF ROSIGLITAZONE IN PHARMACEUTICAL DOSAGE FORMS AND RAT PLASMA

Available:https://ijirt.org/Article?manuscript=152469

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