A NOVEL VALIDATED RP-HPLC METHOD FOR DEVELOPMENT AND ESTIMATION OF ROSIGLITAZONE IN PHARMACEUTICAL DOSAGE FORMS AND RAT PLASMA
Author(s):
Mallikarjun Bere, Dr. Pasham Venkanna
Keywords:
Rosiglitazone (ROZ), Metformin (MF), Rat plasma and RP-HPLC
Abstract
A Simple and rapid RP-HPLC method has been developed and validation of rosiglitazone (ROZ) bulk and in pharmaceutical dosage forms. Metformin (MF) used as an internal standard (IS), the study was performed on a Develosil ODS HG-5 RP C18 (5m,15cmx4.6mm i.d.) with a mobile phase of methanol: potassium dihydrogen phosphate (70:30v/v) as a mobile phase and was delivered at a flow rate of 1.0 ml/min. The detection was carried out at a wavelength of 245nm (Shimadzu-LC 10AD UV detector). The retention time of rosiglitazone was found to be 3.85min respectively. For rosiglitazone, the calibration curve was linear over the concentration range of 120-400 ng/ml for rosiglitazone (UV detector).The method was successfully developed and validated for rosiglitazone estimation, with improved sensitivity, linearity, accuracy and precision as per ICH guidelines and found to be convenient and effective for the estimation of rosiglitazone in pharmaceutical dosage forms and rat plasma.
Article Details
Unique Paper ID: 152469

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 502 - 509
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