"Dissecting Ischemic Stroke: Mechanistic Insights from In Vivo and In Vitro Models"

Mr. Rahul N. Patil; Miss Trupti M.Haral; Mr. Hemant V. Raut; Mr. A. V. Nilangekar; Mr. Sachin Kumar

"Dissecting Ischemic Stroke: Mechanistic Insights from In Vivo and In Vitro Models"

Authors: Mr. Rahul N. Patil, Miss Trupti M.Haral, Mr. Hemant V. Raut, Mr. A. V. Nilangekar, Mr. Sachin Kumar

Unique Paper ID: 168301
Volume: 11
Issue: 5
PageNo: 578-584

Keywords: ischemic stroke; neuroinflammation; oxidative stress; neuroprotection; cellular therapy; drug repurposing

Abstract:
Ischemic stroke remains a leading cause of morbidity and mortality worldwide, necessitating a comprehensive understanding of its underlying pathophysiological mechanisms. Central to ischemic stroke is the disruption of blood flow to the brain, resulting in a cascade of cellular and molecular events, including excitotoxicity, oxidative stress, inflammation, apoptosis, and disruption of the blood-brain barrier. Over the past decades, various in vivo and in vitro models have been developed to dissect the complexity of ischemic stroke, each offering unique mechanistic insights and translational relevance. In vivo models, such as middle cerebral artery occlusion (MCAO), photothrombotic stroke, and embolic stroke, simulate human stroke by inducing localized cerebral ischemia. These models allow for the investigation of stroke dynamics in a physiological environment, providing valuable data on tissue damage, neuroinflammation, and post-ischemic neuroprotection. In vitro models, including oxygen-glucose deprivation (OGD) and organotypic brain slices, enable controlled study of cellular responses to ischemia at the molecular level. These simplified systems offer high-throughput opportunities to explore the neuroprotective potential of novel therapeutic agents.

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ISSN: 2349-6002
Volume: 11
Issue: 5
PageNo: 578-584

"Dissecting Ischemic Stroke: Mechanistic Insights from In Vivo and In Vitro Models"

Available:https://ijirt.org/Article?manuscript=168301

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