Endocrine Pharmacology: Advances in Diabetes and Obesity Treatment

Miss. Sapna Rajendra Zine; Miss Roshani Rajendra Bhavsar; Miss Rachana Pradip chaudhari; Ms Sandhya Hiraman Dhavale; Miss Srushti Jitendra Soni; Mr Omkar  Wavhal

Endocrine Pharmacology: Advances in Diabetes and Obesity Treatment

Authors: Miss. Sapna Rajendra Zine, Miss Roshani Rajendra Bhavsar, Miss Rachana Pradip chaudhari, Ms Sandhya Hiraman Dhavale, Miss Srushti Jitendra Soni, Mr Omkar Wavhal

Unique Paper ID: 173804
Volume: 11
Issue: 10
PageNo: 1498-1503

Keywords: No Keywords Found

Abstract:
Guidelines for managing obesity and type 2 diabetes (T2DM) emphasize the importance of lifestyle modifications, including a reduced-calorie diet and increased physical activity. However, sustaining these changes over the long term can be challenging for many individuals. Pharmacological interventions are available to aid in obesity management by suppressing appetite and/or reducing caloric intake. Incretin-based peptides exert their effects through G-protein-coupled receptors, specifically the receptors for glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These glucagon peptide hormones play a crucial role in regulating insulin secretion and energy metabolism. Understanding the intercellular signaling pathways and inflammatory processes involved in metabolic regulation is essential for developing effective pharmacological agents for obesity. GLP-1 receptor agonists have demonstrated significant success in clinical practice, but their long-term efficacy may be limited due to receptor desensitization and downregulation. An increasing number of new agents targeting incretin hormones are emerging for routine clinical use. These include oral GLP-1 receptor agonists, the dual GLP-1/GIP receptor agonist tirzepatide, and other dual and triple GLP-1/GIP/glucagon receptor agonists, which hold promise for enhanced therapeutic outcomes. This narrative review explores the therapeutic effects of incretin hormones and highlights future advancements in the treatment of T2DM and obesity.

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 10
PageNo: 1498-1503

Endocrine Pharmacology: Advances in Diabetes and Obesity Treatment

Available:https://ijirt.org/Article?manuscript=173804

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