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@article{185182,
        author = {Miss. Priyanka Maurya and Prof. Dr. Amit Kumar Pandey},
        title = {Design, Formulation, And Characterisation of Clarithromycin-Loaded Floating Microballoons For Enhanced Gastric Retention},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {547-551},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185182},
        abstract = {Clarithromycin is a macrolide antibiotic widely used in the treatment of Helicobacter pylori-associated gastric ulcers and other gastrointestinal infections. However, its therapeutic efficacy is limited due to its short biological half-life, incomplete absorption, and variable bioavailability. To overcome these limitations, gastro-retentive drug delivery systems (GRDDS) have been explored. Among them, floating microballoons have gained significant attention because of their low density, prolonged gastric residence time, and ability to provide sustained drug release. The present research aims to design, formulate, and characterise clarithromycin-loaded floating microballoons using suitable polymers by the solvent evaporation technique. Various formulation parameters such as polymer ratio, stirring speed, and solvent system, were optimized to achieve the desired characteristics. The prepared microballoons were evaluated for percentage yield, particle size distribution, drug entrapment efficiency, buoyancy, surface morphology, and in vitro drug release profile. The results demonstrated that the optimised formulation showed high drug entrapment efficiency, prolonged floating ability (>12 h), and sustained drug release in simulated gastric fluid. These findings indicate that clarithromycin-loaded floating microballoons can serve as a promising gastro-retentive delivery system, thereby enhancing gastric retention and improving therapeutic efficacy against H. pylori infection.},
        keywords = {Clarithromycin, Floating Microballoons, Gastric Retention, Gastro-retentive Drug Delivery System, Sustained Release.},
        month = {October},
        }