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@article{188798,
        author = {A. Srinivasa Rao and Bhoompalli Vishnukanth and Sarat Chandra V Miriyala},
        title = {Phytochemical Investigation and Pharmacological Screening of Ipomoea Batatas for Antiinflammation Activity},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {3747-3757},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188798},
        abstract = {The present study aimed to evaluate the anti-inflammatory and antioxidant potential of Ipomoea batatas using various experimental models of inflammation in Wistar rats. Acute and chronic inflammation was induced using carrageenan, dextran, formaldehyde, and serotonin, and the effects of oral administration of Ipomoea batatas extract at low (200 mg/kg) and high (500 mg/kg) doses were compared with the standard anti-inflammatory drug diclofenac (10 mg/kg). Paw edema was measured at specific time points, and biochemical parameters including malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) were estimated to assess oxidative stress and antioxidant activity. The results demonstrated a significant, dose-dependent reduction in paw edema in all models, with the high dose of Ipomoea batatas producing effects comparable to diclofenac. Biochemical analyses revealed decreased MDA levels and increased GSH, SOD, and CAT activities, indicating enhanced antioxidant defense and reduced lipid peroxidation.},
        keywords = {Ipomoea batatas, Anti-inflammatory activity, Paw edema, Oxidative stress},
        month = {December},
        }