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@article{191583,
        author = {Neelesh Kushwaha and REETESH YADAV and DEEPAK PATEL and DILEND PATLE},
        title = {FORMULATION AND EVALUATION OF TASTE MASKED GRANULES OF DROTAVERINE HCL},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {7269-7274},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=191583},
        abstract = {Drotaverine hydrochloride is an antispasmodic drug widely used in the treatment of gastrointestinal and genitourinary disorders. However, its intensely bitter taste can lead to poor patient compliance, especially in pediatric and geriatric populations. The present study was aimed at the formulation and evaluation of taste-masked granules of drotaverine hydrochloride to improve palatability and acceptability. Taste masking was achieved by preparing granules using suitable polymers through an appropriate granulation technique. The prepared granules were evaluated for micromeritic properties, drug content, taste masking efficiency, and in-vitro drug release. Taste evaluation studies indicated a significant reduction in bitterness compared to the pure drug. In-vitro dissolution studies demonstrated that the optimized formulation released the drug rapidly in gastric conditions without affecting its therapeutic performance. The results of the study confirmed that effective taste masking of drotaverine hydrochloride was successfully achieved, leading to improved patient compliance and suitability for oral administration.},
        keywords = {Drotaverine hydrochloride; Taste masking; Granules; Patient compliance; Oral drug delivery system},
        month = {January},
        }