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@article{192200,
        author = {Ashish singh and Dr. Reetesh yadav and Dr Deepak Patel and Dr Pankaj Tiwari},
        title = {SYNTHESISANDBIOLOGICALEVALUATIONOF SUBSTITUTED 2-ALKYL/ARYL BENZIMIDAZOLE DERIVATIVES},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {9},
        pages = {653-659},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=192200},
        abstract = {Benzimidazole and its derivatives represent an important class of heterocyclic compounds due to their wide range of pharmacological activities. In the present study, a series of novel substituted 2-alkyl/aryl benzimidazole derivatives were designed and synthesized to explore their biological potential. The target compounds were synthesized via condensation of o-phenylenediamine with appropriate alkyl/aryl carboxylic acids or their derivatives under suitable reaction conditions. The synthesized compounds were purified and structurally characterized using spectroscopic techniques such as FT-IR, 1H NMR, 13C NMR, and mass spectrometry.
The biological evaluation of the synthesized benzimidazole derivatives was carried out to assess their antimicrobial activity using standard in-vitro assay methods. Several compounds exhibited significant biological activity when compared with standard reference drugs, indicating that substitution at the 2-position of the benzimidazole nucleus plays a crucial role in enhancing biological efficacy. The results suggest that these newly synthesized 2-alkyl/aryl benzimidazole derivatives may serve as promising lead compounds for further optimization and development of novel therapeutic agents.},
        keywords = {Benzimidazole derivatives; 2-alkyl/aryl substitution; Heterocyclic compounds; Synthesis; Spectral characterization; Biological evaluation; Structure–activity relationship},
        month = {February},
        }