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@article{191584,
        author = {Prince Sahu and REETESH YADAV and DEEPAK PATEL and DILEND PATLE},
        title = {FORMULATION DEVELOPMENT OF CONTROLLED RELEASE FORMULATIONS OF LAMIVUDINE AND STAVUDINE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {7633-7639},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=191584},
        abstract = {The combination of Lamivudine and Stavudine is widely used in antiretroviral therapy for the management of HIV infection. However, conventional immediate-release formulations require frequent dosing, which can lead to poor patient compliance and fluctuating plasma drug levels. This study aims to develop and evaluate controlled-release formulations of Lamivudine and Stavudine to enhance therapeutic efficacy and reduce dosing frequency. Various formulation strategies, including matrix systems and release-modifying polymers, were employed to achieve sustained drug release. The formulations were characterized for physicochemical properties, in vitro drug release, and stability. Results demonstrated that the optimized controlled-release formulations maintained therapeutic drug concentrations over an extended period, showing potential for improved patient adherence and clinical outcomes. This work highlights the feasibility of developing sustained-release antiretroviral dosage forms for enhanced HIV therapy.},
        keywords = {Lamivudine, Stavudine, Drug delivery systems, HIV, Patient compliance},
        month = {January},
        }