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@article{191681,
        author = {VARSHA RAJAK and DR REETESH YADAV and DR DEEPAK PATEL and DILEND PATLE},
        title = {PREPARATION AND CHARACTERIZATION GLIPIZIDE LOADED NANOPARTICLES},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {7626-7632},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=191681},
        abstract = {Glipizide is a second-generation sulfonylurea widely used in the management of type 2 diabetes mellitus; however, its therapeutic efficacy is limited by poor aqueous solubility, variable gastrointestinal absorption, and short biological half-life, leading to frequent dosing and fluctuating plasma drug levels. The present study aims to develop and characterize glipizide-loaded nanoparticles to enhance its solubility, sustain drug release, and improve oral bioavailability.
Glipizide-loaded nanoparticles were prepared using a suitable polymeric system such as poly (lactic-co-glycolic acid) (PLGA) or chitosan by the nanoprecipitation/emulsification–solvent evaporation method. The formulation variables, including polymer concentration, drug-to-polymer ratio, surfactant concentration, and stirring speed, were optimized to obtain nanoparticles with desirable physicochemical properties. The prepared nanoparticles were characterized for particle size, polydispersity index (PDI), and zeta potential using dynamic light scattering techniques. Drug entrapment efficiency and drug loading capacity were determined by UV-visible spectrophotometry.
Compatibility between glipizide and excipients was evaluated using Fourier Transform Infrared Spectroscopy (FTIR), while the physical state and crystallinity of the drug were analyzed by Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD) studies. Surface morphology of the nanoparticles was examined using Scanning Electron Microscopy (SEM) or Transmission Electron Microscopy (TEM). In vitro drug release studies were performed using suitable dissolution media to assess the release kinetics and mechanism.
The results demonstrated that glipizide was successfully encapsulated within the nanoparticles, producing a nanosized, stable formulation with sustained drug release characteristics. The developed glipizide-loaded nanoparticles show promise as an effective oral drug delivery system for improved diabetes management.},
        keywords = {Glipizide; Nanoparticles; Polymeric drug delivery system; Nanoprecipitation; Entrapment efficiency; Sustained release; Characterization; Type 2 diabetes mellitus; PLGA; Chitosan},
        month = {January},
        }