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@article{205783,
        author = {Ammireddy Jayasree and G Srinivasa Rao and P V Sreedhar Reddy and Guduru Rajeswari},
        title = {PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF Aspidosperma Tomentosum AGAINST SCIATIC NERVE LIGATION-INDUCED NEUROPATHIC PAIN IN RATS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {7754-7757},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205783},
        abstract = {Neuropathic pain is a chronic debilitating condition resulting from injury or dysfunction of the nervous system and is characterized by hyperalgesia, allodynia, spontaneous pain, and behavioral abnormalities. Conventional therapies including antidepressants, anticonvulsants, and opioids provide only partial relief and are often associated with adverse effects. Therefore, the search for safer and effective therapeutic alternatives from natural sources has gained significant attention. The present study was designed to evaluate the protective effect of ethanolic extract of Aspidosperma tomentosum (EEAT) against sciatic nerve ligation (SNL)-induced neuropathic pain in rats. Male Wistar rats were divided into four groups: Sham control, SNL control, EEAT 200 mg/kg, and EEAT 400 mg/kg. Neuropathic pain was induced by partial sciatic nerve ligation and treatment was continued for 14 days. Pain threshold was assessed using foot deformity score and tail withdrawal latency tests. Behavioral parameters such as motor coordination, spontaneous locomotor activity, and transfer latency were evaluated. Oxidative stress markers including malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD) were estimated in sciatic nerve homogenates. Results demonstrated that EEAT significantly attenuated neuropathic pain, improved behavioral deficits, restored antioxidant enzyme levels, and reduced lipid peroxidation. The findings suggest that Aspidosperma tomentose possesses significant neuroprotective and antineuropathic activity, possibly mediated through antioxidant mechanisms.},
        keywords = {Aspidosperma tomentose, Neuropathic Pain, Sciatic Nerve Ligation, Oxidative Stress, Antioxidant Activity, Neuroprotection},
        month = {June},
        }