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@article{153288,
        author = {Ms. Priyal Shah and Dr. Anuradha Gajjar},
        title = {Development and Validation of Stability Indicating RP-HPLC Method for Efonidipine Hydrochloride ethanolate},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {8},
        number = {6},
        pages = {340-345},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=153288},
        abstract = {The paper describes development and validation of a stability indicating chromatographic assay method for Efonidipine Hydrochloride ethanolate (EFD) in solid pharmaceutical dosage form. EFD and degradant products under varied stress conditions like hydrolysis at a range of pH, temperature, oxidation  and exposure to light were analysed by developed RP-HPLC method with proper separation as well as good peak shape. The developed method consisted of mobile phase Methanol: water (50:50 v/v). The flow rate was 0.8 mL/min with a run time of 10 min and detection at 270 nm. The assay was performed on marketed formulation that showed 99.52% labelled claim. During the forced degradation studies, Efonidipine showed maximum degradation (10 %) under oxidative stress followed by 8 % photodegradation. The drug showed lower degradation under acid, base and thermal stress conditions, to the extent of 4 %, 3 % and 6 % respectively. It was also observed that the retention time of the degradant under photolytic and oxidative degradation were the same probably due to the formation of the same product. },
        keywords = {Efonidipine hydrochloride ethanolate, Stability indicating assay method, stress conditions, anti-hypertensive, photodegradation.},
        month = {},
        }