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@article{185789,
        author = {SAGAR SAHU and REETESH YADAV and DEEPAK PATEL and DILEND PATLE},
        title = {Novel Thiadiazole Derivatives: Synthesis, Structural Characterization, and Pharmacological Evaluation},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {3089-3094},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185789},
        abstract = {Thiadiazole derivatives are well-known for their broad spectrum of biological activities and have attracted significant attention in medicinal chemistry. In this study, a series of novel thiadiazole compounds were synthesized from 5-substituted-2-amino-1,3,4-thiadiazole precursors using various condensation and substitution reactions. The synthesized compounds were structurally characterized by spectroscopic techniques including FT-IR, ¹H NMR, ¹³C NMR, and mass spectrometry, confirming the proposed molecular frameworks. The biological activities of the synthesized derivatives were evaluated for their antimicrobial, anti-inflammatory, and antioxidant potentials using standard in vitro assays. Several compounds demonstrated promising pharmacological profiles, indicating that substitution at specific positions on the thiadiazole ring significantly influences biological activity. The findings suggest that these novel thiadiazole derivatives could serve as potential leads for further drug development.},
        keywords = {Thiadiazole derivatives, 5-substituted-2-amino-1,3,4-thiadiazole, synthesis, structural characterization, FT-IR, NMR, pharmacological evaluation, antimicrobial activity, anti-inflammatory, antioxidant.},
        month = {October},
        }