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@article{185859,
        author = {Dr. Shubhangi Shahu Sonavane and Dr.Varsha Vinayak Shejale and Prof.Dr. Prasanna T Gavali},
        title = {MEDHYA RASAYANA PLANTS: TRADITIONAL CLAIMS AND MODERN NEUROPROTECTIVE EVIDENCE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {3429-3433},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185859},
        abstract = {Medhya Rasayana, a unique concept in Ayurveda, refers to a group of rejuvenative herbs that enhance intellect (Medha), memory, and overall cognitive functions. These plants are believed to nourish the nervous system, improve mental clarity, and promote emotional stability. Classical Ayurvedic texts such as Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya describe four principal Medhya Rasayana drugs—Mandukaparni (Centella asiatica), Yashtimadhu (Glycyrrhiza glabra), Guduchi (Tinospora cordifolia), and Shankhapushpi (Convolvulus pluricaulis). Each possesses distinct pharmacological properties, such as Medhya, Smritikara, and Buddhivardhaka, which are associated with the nourishment of Majja Dhatu and stabilization of Manovaha Srotas. Modern pharmacological research has validated many of these traditional claims, revealing neuroprotective effects through antioxidant, anti-inflammatory, and neurogenesis-promoting mechanisms. Centella asiatica demonstrates synaptic plasticity and neuronal repair; Tinospora cordifolia modulates stress and neuroinflammation; Glycyrrhiza glabra exhibits anti-oxidative and anti-depressive effects; while Shankhapushpi enhances cholinergic transmission and memory retention. Collectively, these herbs show promise in managing neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and cognitive decline associated with aging. Integrative studies suggest that Medhya Rasayana may regulate neurotransmitters like acetylcholine, serotonin, and dopamine, thus bridging the gap between traditional wisdom and neurobiological science. The convergence of Ayurvedic Rasayana principles with modern neuropharmacology opens new therapeutic avenues for cognitive enhancement, stress management, and prevention of neuronal degeneration. However, further clinical and molecular studies are essential to standardize formulations, validate safety, and establish evidence-based protocols for global acceptance.},
        keywords = {Medhya Rasayana, Neuroprotection, Ayurveda, Cognitive enhancement, Centella asiatica, Tinospora cordifolia, Glycyrrhiza glabra, Convolvulus pluricaulis, Neurodegenerative disorders, Antioxidant activity.},
        month = {October},
        }