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@article{187351,
        author = {Mr. Krishna V. Chavan and Miss. Bhagyashali Baheti},
        title = {HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) IN QUALITY CONTROL},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {3868-3874},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187351},
        abstract = {High-Performance Liquid Chromatography (HPLC) has evolved into one of the most powerful and indispensable analytical techniques in the pharmaceutical, food, environmental, and cosmetic industries for ensuring product quality, safety, and regulatory compliance. As a highly sensitive, accurate, and reliable separation method, HPLC plays a central role in routine Quality Control (QC) testing by enabling the qualitative and quantitative analysis of active pharmaceutical ingredients (APIs), impurities, degradation products, excipients, and contaminants. Its wide applicability to thermally unstable, polar, and nonvolatile compounds provides a significant advantage over conventional chromatographic methods. In pharmaceutical QC, HPLC supports assay determination, impurity profiling, dissolution testing, stability studies, and validation of analytical methods, thereby ensuring that products meet established pharmacopeial and regulatory standards. The technique also offers exceptional flexibility through a variety of modes—such as reverse-phase, ion-exchange, size-exclusion, and chiral chromatography—allowing precise customization based on sample characteristics. Advances in column technology, detectors, and automated data acquisition systems have further enhanced the resolution, reproducibility, and speed of HPLC analysis. As regulatory authorities increasingly emphasize robust quality assurance practices, HPLC continues to be the method of choice for developing validated, reliable, and reproducible QC methods. Overall, HPLC remains a cornerstone analytical tool that significantly enhances the accuracy, consistency, and credibility of quality control processes across multiple scientific and industrial sectors.},
        keywords = {High-Performance Liquid Chromatography (HPLC)},
        month = {November},
        }