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@article{187814,
        author = {Ms. Ashwini C. Barde and Mr. Akshay R. Gadhari},
        title = {FORMULATION AND DEVELOPMENT OF IMMEDIATE RELEASE TABLET OF CHLOROQUINE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {6360-6368},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187814},
        abstract = {Chloroquine remains one of the most widely used antimalarial agents, particularly in regions where its therapeutic efficacy is still relevant despite emerging resistance. Developing an immediate-release (IR) tablet formulation of chloroquine is essential for ensuring rapid onset of action, improved patient compliance, and consistent bioavailability. This review article provides a comprehensive overview of the formulation strategies, excipient selection, manufacturing techniques, evaluation parameters, and quality considerations involved in the development of chloroquine IR tablets. Key preformulation studies, such as physicochemical characterization, solubility profiling, and drug–excipient compatibility, are discussed to highlight their role in optimizing tablet performance. In addition, the review examines essential evaluation parameters such as disintegration time, dissolution rate, mechanical strength, stability studies, and overall pharmacotechnical performance. Published literature indicates that optimized formulations can achieve rapid drug release within the first few minutes, aligning with pharmacopeial requirements for IR dosage forms. Overall, this review consolidates current advancements, challenges, and formulation considerations for developing chloroquine immediate-release tablets. It highlights the importance of carefully selecting excipients, optimizing processing variables, and conducting thorough quality control testing to ensure safety, efficacy, and regulatory compliance. The insights provided can guide formulation scientists in designing robust, efficient, and patient-centric IR tablet formulations of chloroquine.},
        keywords = {Chloroquine; Immediate release tablet; Formulation development; Superdisintegrants; Preformulation studies; Dissolution.},
        month = {November},
        }