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@article{187815,
        author = {Ms. Priyanka K. Adhav and Mr. Akshay R. Gadhari},
        title = {FORMULATION AND DEVELOPMENT OF IMMEDIATE RELEASE TABLET OF AMOXICILLIN},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {6315-6323},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187815},
        abstract = {The formulation and development of immediate release (IR) tablets of Amoxicillin remain a crucial area of research in modern pharmaceutical technology due to the drug’s extensive use as a first-line antibiotic for a variety of bacterial infections. Immediate release dosage forms are designed to disintegrate rapidly and ensure prompt drug dissolution, thereby achieving quick therapeutic action. This review article focuses on the critical formulation considerations, excipient selection, manufacturing approaches, and evaluation parameters associated with developing an effective Amoxicillin IR tablet. Key formulation aspects such as the choice of diluents (microcrystalline cellulose, lactose), disintegrants (croscarmellose sodium, sodium starch glycolate), binders (PVP-K30, HPMC), and lubricants (magnesium stearate) are discussed in detail, emphasizing their impact on tablet hardness, friability, disintegration time, and dissolution behavior. Furthermore, the article examines preformulation studies necessary for understanding physicochemical properties of Amoxicillin, such as solubility, stability, and compatibility with excipients. Various manufacturing techniques including direct compression, dry granulation, and wet granulation are compared, highlighting their suitability based on powder characteristics and desired release patterns. Overall, this article consolidates existing research and provides comprehensive insights into optimizing formulation strategies for Amoxicillin immediate release tablets. Such optimization ensures enhanced bioavailability, improved patient compliance, and consistent product performance.},
        keywords = {Amoxicillin; Immediate Release Tablets; Formulation Development; Preformulation Studies; Excipients; Direct Compression; Wet Granulation; Drug Release.},
        month = {November},
        }