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@article{204233,
        author = {Ms. Aditi Badrinath Pungle and Mr. Milke U. R. and Dr. Sheikh S.S.},
        title = {FORMULATION AND EVALUATION OF THE THEOPHYLLINE SUSTAIN RELEASE MATRIX TABLET},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {1508-1520},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204233},
        abstract = {The present study was aimed at the formulation and evaluation of sustained release matrix tablets of Theophylline to prolong drug release, improve therapeutic efficacy, and reduce dosing frequency. Theophylline, a bronchodilator widely used in the management of asthma and chronic obstructive pulmonary disease (COPD), possesses a short biological half-life, requiring frequent administration. Sustained release matrix tablets were developed to maintain a constant plasma drug concentration for an extended period and enhance patient compliance.
The sustained release matrix tablets of Theophylline were prepared using the direct compression or wet granulation technique with different concentrations of hydrophilic and hydrophobic polymers such as hydroxypropyl methylcellulose (HPMC), ethyl cellulose, and carbopol as release-retarding agents. The prepared formulations were evaluated for pre-compression parameters including angle of repose, bulk density, tapped density, Carr’s index, and Hausner’s ratio to assess flow properties of granules. Post-compression evaluation was carried out for hardness, thickness, friability, weight variation, drug content uniformity, and in vitro dissolution studies.
The dissolution profile demonstrated sustained drug release over an extended period, depending on the concentration and type of polymer used. Among the formulations, the optimized batch exhibited satisfactory physicochemical characteristics and controlled drug release following suitable kinetic models. The study concluded that sustained release matrix tablets of Theophylline can be successfully formulated to improve bioavailability, reduce dosing frequency, and enhance patient compliance in long-term therapy of respiratory disorders.},
        keywords = {},
        month = {June},
        }