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@article{184294,
        author = {Mohammad Zaid Mansoori and DR REETESH YADAV and DR DEEPAK PATEL and DILEND PATLE},
        title = {Design, Synthesis, and In-Depth Biological Assessment of Novel 2-[(E)-2-Substituted-Ethenyl]-1,3-Benzoxazole Derivatives},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {4},
        pages = {904-912},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=184294},
        abstract = {Using 2-methylbenzoxazole derivatives and suitably substituted aldehydes, a systematic condensation procedure was used to create a novel series of 2-[(E)-2-substituted-ethenyl] derivatives of 1,3-benzoxazoles. Mass spectrometry, FT-IR, ¹H NMR, ¹³C NMR, and other spectroscopic methods were used to confirm the molecular frameworks and stereochemistry of the produced compounds. Their antibacterial, antioxidant, and cytotoxic properties were evaluated through a thorough biological analysis. Numerous compounds showed excellent antioxidant activity in DPPH experiments and noteworthy antibacterial potency against both Gram-positive and Gram-negative bacterial strains, indicating significant biological value. The crucial impact of electron-donating and electron-withdrawing substituents on biological outcomes was demonstrated by the structure-activity relationship (SAR) research. According to these results, 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazole compounds have a great deal of promise as therapeutic scaffolding for additional drug development.},
        keywords = {DPPH, 2-methylbenzoxazole, 1,3-benzoxazoles, Mass spectrometry, 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazole, Antibacterial. Antioxidant Activity Assays, Synthesis, and Characterization},
        month = {September},
        }