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@article{187694,
        author = {S. Manoj Babu and Dr. A. K Sharma},
        title = {EXPLORING THE ROLE OF METABOLOMICS IN FEMALE INFERTILITY THROUGH A COMPREHENSIVE STUDY OF FOLLICULAR ENVIRONMENT, GAMETE QUALITY, AND EMBRYO METABOLISM},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {8},
        pages = {3606-3619},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187694},
        abstract = {Female infertility is a complex disorder, which impacts a great percentage of the world population. Knowledge of its underlying causes must be a multifactorial strategy, which encompasses the assessment of the follicular environment, quality of gametes, and embryo development. This paper will examine how metabolomics can be used to identify and treat the infertility of females by examining the metabolic composition of principal reproductive tissues and fluids, such as follicular fluid, oocytes and embryos. With the help of metabolomics, it is possible to obtain useful information on the biochemical alterations within the reproductive system and identify the interruptions in the metabolic processes that disrupt fertility. Metabolomics using metabolite profiling of glucose, lactate, pyruvate, amino acids and oxidative stress can provide predictive biomarkers of embryo quality, oocyte maturation and implantation potential. This method enables non-invasive measurements of embryo health which give more effective and dynamic alternatives to the conventional methods such as embryo biopsy and morphological grading. Metabolomic profiling is set to enhance fertility methods by assisting the process of embryo screening, amplifying implantation rates and customizing treatment in Assisted Reproductive Technologies (ART), including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Although metabolomics is promising, there are challenges associated with the application of the technology, such as technical, financial, and regulatory, as well as the necessity of standardized protocols and mass validation. Nevertheless, with the advancements in research, metabolomics will transform the field of fertility diagnostics to provide more specific, non-invasive, and personalized treatment of female infertility. Necessary further research is needed to determine the metabolomic biomarkers as valid means of clinical practice and to revise the incorporation of metabolomics into ART protocols.},
        keywords = {Female Infertility, Metabolomics, Follicular Environment, Gamete Quality.},
        month = {November},
        }