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@article{204761,
        author = {Rashmi Tanajirao Deshmukh and Dr. A.U. Bindu},
        title = {Formulation Development And Characterization Of Novel Antipsoriatic Gel For Topical Drug Delivery Sysyem.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {6859-6867},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204761},
        abstract = {Compatibility between the drug and excipients was confirmed through Fourier Transform Infrared (FTIR) spectroscopy studies, indicating no significant interactions. The gel formulation was prepared using dimethyl sulfoxide (DMSO), Carbopol 10NF, propylene glycol, glycerol, methyl paraben, propyl paraben, and purified water.
Among all the formulations developed, Formulation F3 was identified as the optimized formulation due to its superior performance. The prepared gel exhibited satisfactory physicochemical properties, including an assay value of 97% w/w and a pH of 4.99, indicating good drug content uniformity and suitability for topical application.
In vitro drug diffusion studies demonstrated that the optimized formulation released 98.2% of the drug within 12 hours, suggesting sustained and effective drug release. Furthermore, stability studies were conducted by storing the formulation under accelerated conditions of 40°C/75% RH and 30°C/65% RH for periods of one, two, and three months.
The results showed that the optimized formulation (F3) maintained its physical characteristics, drug content, and release profile throughout the study period, demonstrating good stability and satisfactory in vitro performance. These findings indicate that Formulation F3 is a promising gel formulation with potential for effective therapeutic application.},
        keywords = {},
        month = {June},
        }