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@article{206044,
        author = {Karuna Baliram Chandboodhale and Mr. L. R. Bagwan.},
        title = {Formulation And Evaluation Of Microspheres By Using Spray Drying Technique},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {2796-2805},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206044},
        abstract = {Ketoprofen is one noninflammatory drug (NSAID). drug belongs to the class of NSAIDs.The work plan has been divided into different portions because it is a BCS class II medicine. First obtaining theoretical information by conducting a pharmacological profile and literature study. The next step was to acquire materials and standardize them. To ascertain the color, taste, flavor, and melting   point of the drug, reformulation studies were carried out. 
The findings demonstrated that these attributes matched those listed in the medication material's analytical profile. The compatibility examination utilizing FTIR spectroscopy and an FTIR spectrophotometer revealed no interaction between the medication and carrier.
The ketoprofen microspheres were made by spray drying ethyl cellulose, Eudragit RS, Eudragit RL, and Eudragit E100 as rateretarding polymers. The generated formulations were evaluated using a range of metrics, such as practical yield, micromeritic analysis, particle size measurement, drug content, invitro drug release, scanning electron microscopy (SEM), and stability studies. SD showed better flow properties, according to the micromeritic analysis. Furthermore, it was shown that the techniques employed in this work to produce spray dried microspheres may produce a formulation with a constant drug content. By using in vitro sink conditions with the proper dissolving media, we can gain additional insight into how the medication will function inside the body.
Alongside the dissolution research, two aspects are looked at: the amount of drug solubilized and the pace of dissolution. The invitro study found that an increase in carrier concentration speeds up the rate of dissolution. A faster rate of disintegration was observed in the order of A good solubility profile depends on the drug staying in its amorphous form in the formulation, which stability tests guarantee. Following two months of stability testing at 40ºC and 75% relative humidity, the drug content and dissolution of the selected optimal formulation were evaluated. The findings of the alter analysis showed no significant changes in the physical appearance, drug content, or in vitro drug release.},
        keywords = {},
        month = {July},
        }